FMD Vaccine (Type O, A, Asia 1) Description
This trivalent inactivated vaccine is formulated to protect livestock against three major serotypes of foot-and-mouth disease virus (FMDV): Type O, Type A, and Asia 1. These serotypes are widely distributed across Asia, the Middle East, and parts of Africa, posing a significant threat to cattle and small ruminant industries.
Foot-and-mouth disease is a highly contagious viral disease characterized by fever, vesicular lesions, lameness, and severe production losses, including reduced milk yield and weight gain. Rapid transmission and economic impact make vaccination a critical component of national and regional disease control programs.
The vaccine is produced using suspension culture technology and contains high-potency antigen levels (≥ 10⁷.⁵ LD50 per 0.2 mL before inactivation for each strain), ensuring strong immunogenicity. The oil emulsion formulation enhances antigen presentation and prolongs immune response duration.
Following vaccination, animals develop protective immunity lasting up to 6 months, making this vaccine suitable for routine immunization and large-scale preventive programs, including government vaccination campaigns.
Immunization Program
- Routine vaccination every 6 months
- Suitable for integration into national FMD control strategies
- Recommended for both endemic and high-risk regions
Dosage & Administration
- Route: Intramuscular injection (neck region)
- Cattle: 2.0 mL per animal
- Sheep/Goats: 1.0 mL per animal
Antigen Composition
Each component contains (before inactivation):
- Type O (Strain OHM/02): ≥ 10⁷.⁵ LD50 / 0.2 mL
- Type A (Strain AKT-III): ≥ 10⁷.⁵ LD50 / 0.2 mL
- Asia 1 (Strain Asia 1 KZ/03): ≥ 10⁷.⁵ LD50 / 0.2 mL
Product Characteristics
- Appearance: Milky white or light pink viscous emulsion
- Stable oil-based formulation for enhanced immune response
- Suitable for large-scale livestock vaccination
Safety & Adverse Reactions
Common reactions:
- Local swelling at injection site
- Temporary fever
- Reduced feed intake (1–2 days)
- Temporary drop in milk production (dairy cattle)
These symptoms are generally mild and self-limiting.
Severe reactions (rare):
- Acute hypersensitivity:
- Restlessness
- Rapid breathing
- Muscle tremors
- Mucosal congestion
- Rumen bloating
- In rare cases:
- Death if not treated promptly
- Possible abortion in pregnant cattle
Emergency treatment:
- Immediate administration of epinephrine
- Supportive veterinary care
Packaging & Specification
- Specification: 100 mL/bottle
- Packaging: 100 mL × 50 bottles/carton
Storage & Shelf Life
- Storage: 2–8°C
- Do NOT freeze
- Protect from sunlight
- Shelf Life: 12 months
Precautions
- Bring vaccine to room temperature and shake well before use
- Do not use frozen vaccine
- Use caution in diseased or weak animals
- Perform small-scale trial before mass vaccination if necessary
- Maintain aseptic injection procedures
- In outbreak situations:
- Combine vaccination with comprehensive control measures (biosecurity, movement control, surveillance)
- Dispose of vaccine residues and materials safely
